How did average weight loss go from 8 to 29 percent?
GLP-3 mimics three biological signals:
appetite, sugar and fat burning.
Four compounds. One decade.
Each generation targets more of the body’s metabolic pathways.
Signal 1
Appetite ControlGLP-1
Full faster and reduces hunger
Signal 2
Metabolic SupportGIP
Process sugars and fats more efficiently
Signal 3
Energy ReleaseGlucagon
Uses stored fat as energy
2025
Retatrutide
28.7%Average Weight Loss
2022
Mounjaro / Zepbound
22.5%Average Weight Loss
2021
Ozempic / Wegovy
15%Average Weight Loss
2015
Saxenda
8%Average Weight Loss
What the research shows
About GLP-3
Body Composition
29% Average weight loss
76% Improvement in joint pain
1 in 8 Reported complete pain relief
Cardiovascular
14-pt Drop in blood pressure
27% Drop in non-HDL cholesterol (Harmful type)
41% Reduction in triglycerides (Blood fats)
Metabolic
86% Average liver fat reduction
93% Saw liver fat return to normal
71% Drop in fasting insulin
GLP-3 RT
Three targets. One peptide
- GLP-1 Regulates the hunger signal
- GIP Regulates how the body processes fat and sugar
- Glucagon Signals the body to use stored energy
Research use onlyGet GLP-3 →
For educational purposes only. Not medical advice. Consult a healthcare professional