How did one signalling pathway become three?
GLP-3 acts on three signalling pathways:
GLP-1, GIP and glucagon.
Four compounds. One decade.
Each generation targets more of the body’s metabolic pathways.
Signal 1
GLP-1 receptorGLP-1
Carries the satiety signal from gut to brain
Signal 2
GIP receptorGIP
Acts on glucose handling and on fat tissue
Signal 3
Glucagon receptorGlucagon
Tells the liver to release stored energy
2025
Retatrutide
3Receptors targeted
2022
Tirzepatide
2Receptors targeted
2021
Semaglutide
1Receptors targeted
2015
Liraglutide
1Receptors targeted
What the Phase 3 trials measured
About GLP-3
Body Composition
Body weight
Joint pain
Pain relief reporting
Cardiovascular
Blood pressure
Non-HDL cholesterol
Triglycerides
Metabolic
Liver fat
Liver fat normalisation
Fasting insulin
GLP-3 RT
Three targets. One peptide
- GLP-1 carries the satiety signal from gut to brain
- GIP acts on glucose handling and on fat tissue
- Glucagon tells the liver to release stored energy
Research use onlyGet Catalyst →
For educational purposes only. Not medical advice. Consult a healthcare professional.